Our Team


weinberg.jpg

Peter Weinberg

Professor Peter Weinberg won a scholarship to Cambridge, where he read Natural Sciences. He then obtained a DIC, MSc and PhD from Imperial College, the latter being supervised by Colin Caro in the Physiological Flow Studies Unit. After being awarded a Lady Davis Fellowship in the Dept of Bioengineering at the Technion, Israel, and further postdoctoral studies in the Physiological Flow Studies Unit, he was appointed Lecturer and then Reader in the School of Animal and Microbial Sciences,University of Reading. During this period he was also a Visiting Senior Research Fellow in the Centre for Cardiovascular Biology & Medicine, King’s College London. In 2004 he returned to Imperial College as a Reader in the Department of Bioengineering, and was appointed Professor of Cardiovascular Mechanics there in 2007. He has served as Director of Postgraduate Studies (Research) (2004-2007) and Director of Research (2006-2014) for the Department.

Professor Weinberg’s research is chiefly concerned with elucidating mechanisms involved in the development of atherosclerosis. He has developed a new theory relating the anatomically patchy distribution of atherosclerosis to variation in blood flow, endothelial nitric oxide synthesis and uptake of plasma macromolecules by the arterial wall. He is also developing methods of pulsewave analysis for assessing nitric oxide synthesis non-invasively, and has studied the large differences in vascular fluid mechanics that occur between species of different size.

More recent work has focused on the role played by wall uptake of plasma macromolecules in the pathogenesis of vulnerable plaques, on improving methods for non-invasively measuring blood flow patterns, and on developing new methods for studying arterial wall permeability in vitro and in silico. The work has been funded by BBSRC, EPSRC, MRC, The Royal Society, BHF and the Wellcome Trust.

He has been elected Fellow of the Royal Microscopical Society, Ordinary Member of the Physiological Society, Member of the British Atherosclerosis Society, Committee Member of the London Microcirculation Group, Committee Member of the British Society for Cardiovascular Research and Committee Member of the British Atherosclerosis Society. He founded (2008) and chaired (2011-2014) the UK’s Bioengineering Society, was an invited member of the Cardiovascular Technical Advisory Committee of IMechE’s Engineering in Medicine and Health Division and sat on the Project Grants Committee of the British Heart Foundation. He has helped organise numerous national and international symposia, was an Associate Editor (and is now an Editorial Board Member) of Atherosclerosis, and he serves on the Heart Research UK Novel and Emerging Technologies (NET) Grant Panel. He has supervised over 50 Fellows, Research Assistants, Technicians and PhD students, four of whom have obtained academic positions. In 2014 he won the Imperial College President’s Award for Excellence in Research Supervision.

Click here to visit his Imperial College Personal Webpage

Email Peter


 
rowland.png
 

Ethan Rowland

I graduated from Durham University in 2008 with a first class MEng Hons degree in Aeronautics, working on computational modelling of membrane wings in my final year. It was this that led to an interest in physiological modelling after drawing parallels with biological tissue constitutive models.

I joined Imperial College in 2009 having been awarded a 4-year studentship with the BHF Centre of Research Excellence. My first year saw the completion of a MRes course, working on two 6-month research projects with Prof. Peter Weinberg and Prof. Spencer Sherwin investigating the role of haemodynamics in atherosclerosis. These resulted in my current PhD work, investigating the mechanical determinants of endothelial cell (EC) morphology in relation to vascular disease. The non-uniform distribution of atherosclerotic lesions within the arterial system correlates spatially with variations in EC morphology.

Whilst there is substantial evidence that morphology is affected by haemodynamic wall shear stress (WSS), wall strain is also known to align and elongate cells perpendicular to the direction of stretch. Using computational fluid dynamics and novel techniques to characterize local strains, this study aims to establish the relative importance of shear and strain in determining EC morphology in vivo. Insight into the role of wall strain in atherosclerosis may open up potential new avenues for intervention in the disease process. More immediately the results would have relevance to the many studies that use EC morphology as a surrogate index of mean WSS.

Email Ethan


 
toulemonde.jpg
 

MATTHIEU TOULEMONDE

I studied Physics and Chemistry at l’Université Jean Monnet in Saint-Etienne (France) (graduated (Licentiate) 2009) then studied Optic, Image and Signal processing at l’Université Jean Monnet, (graduated M. Sc. Title 2011). During this time, I did two internships, firstly in Finland (2010) working on the scattering of Red Blood cells trapped with Optical Tweezers and secondly in France (2011)  in the LASPI laboratory where I worked on the vibration impact on the human body for osteoporosis.

In September 2011 I started my PhD in co-agreement between the Université Lyon 1 (France) and the Università di Firenze (Italy). In 2014 I completed my doctorate thesis on new beam forming strategy for improved ultrasound imaging: application to biological tissues nonlinear imaging. During my Ph.D I worked in two laboratories: CREATIS (Lyon, France,) and MSDLab (Florence, Italy).

I improved the ultrasound image quality (speckle noise reduction), the nonlinearity parameter estimation by echographic image, the CREANUIS software and created an ultrasound pressure field platform in order to characterize the pressure field of probes with Labview and Matlab software.

Since October 2014 (until August 2015) I have been a part-time Post-doc in the ultrasound team in CREATIS and I teach in the Université Lyon 1. In March 2015, I started part-time as a Research Associate in the Ultrasound Imaging Group at Imperial College at London working on ultrafast Contrast Enhanced Ultrasound (CEUS) imaging for echocardiographic application.

Email Matthieu and view his list of Publications: CREATIS 


Mean Ghim

I joined Imperial College in 2006, studying for a BEng in biomedical engineering followed by an MSc in biomedical engineering. In 2012, I joined Professor Weinberg’s research group on a 3-year bioengineering departmental funded PhD studentship.

I am currently working on a project investigating the effects of endothelial permeability exposed to shear stress in vitro. There have been a few studies that have applied physiological shear stress to endothelial cells and many have only concentrated on the effects of acute shear stress.

We propose that different patterns of chronically applied shear stress have varying consequences on endothelial permeability and any change in permeability is mediated by modification of junctional complexes. The main aim of the project will be develop a method to produce spatially resolved permeability measurements of endothelial cells and to observe the effect of junctional molecules on endothelial permeability in conjunction with various chronic patterns of shear stress in vitro.

Email Mean


arshad.jpg

Mehwish Arshad

I graduated from Queen Mary University of London in 2015 with a MEng hons degree in Medical Engineering. My previous projects include exploration and characterisation of novel protein/peptide assemblies as new hybrid biomaterials and engineering a device to support a microfluidic system for metastasis on a Chip. In the latter project I was specifically involved with the design and modelling of the device using AutoCAD and computational fluid dynamics.

I am currently an MRes student at Imperial College London studying biomedical research in cardiovascular science. My research focuses on determining what characteristics of wall shear stress are though to trigger atherosclerosis and to also characterize which pathways are controlling permeability and cholesterol transport across the endothelium in atherosclerosis.

Email Mehwish


dazzi.jpg

Marta Dazzi

I read Chemistry (MChem) at Brasenose College, University of Oxford. As part of my final year project I developed a high-throughput screening technique to assess inhibitor potency for oxygen-sensing enzymes. I am now part of the first ever cohort for the Medical Imaging Centre for Doctoral Training at King’s College London and Imperial College London. In my first year I was awarded an MRes in Medical Imaging Sciences at King’s College London where I investigated and synthesised functionalised gold nanoparticles for theranostic purposes. This led to my interest in the use of MRI contrast agents to image biological functions.

So far the group has used confocal microscopy to quantify endothelial permeability in mice. However, this makes use of excised tissue. Much insight into the process of atherosclerosis could be gained by in vivo real-time techniques. My PhD involves the use of an albumin-binding contrast agent, Gadofosveset Trisodium. The use of albumin is used to mimic the transport of plasma macromolecules into the artery wall and thus image endothelial permeability in mice and humans.

Click here to visit my CDT profile.

Email Marta


 
riemer.jpg
 

kai riemer

Studying for a Mres/PhD in the Investigation of the roles of blood flow and inflammation in cardiovascular disease using novel ultrasound Imaging technology and confocal microscopy.

Previously:

  • Research Associate at German Heart Institute Berlin (DHZB, Germany) working on congenital heart defects and the development of a novel bioprosthetic heart valve

  • M.Sc. Biomedical Engineering (TU Berlin, Germany) working on biofluid mechanics and the development of an automated error correction using passive BCI for defined movement pattern of a hand prosthesis

Email Kai


 
reavette.png
 

Ryan Reavette

For my undergraduate degree I studied Mathematics and Physics at the University of York. My final year project was on hydrodynamic stability theory and involved deriving and applying criteria for instability in cases involving velocity shear, thermal convection, and differential rotation. Following this, I worked for a year at the technology consultancy BAE Systems Applied Intelligence, before joining the CDT in Fluid Dynamics across Scales on a four year studentship here at Imperial.

For my first year, I was based in the Department of Mathematics. I was awarded an MRes degree after completing a research project on dynamo theory, which explores the mechanism by which the motion of an electrically conducting fluid may generate a self-exciting magnetic field. It’s generally accepted as the explanation for the magnetic fields of planets and stars. 

My PhD research can be broadly split into two parallel streams: the first involves computational modelling of arterial haemodynamics, with a focus on the developing of models which incorporate the non-linear behaviour of the arterial wall; the second involves wave intensity analysis, and in particular evaluating its potential as a non-invasive method for diagnosing heart failure. 

Email Ryan


Adele Lam

I graduated from the National University of Singapore in 2017 with a BEng in Biomedical Engineering, and have just recently completed my MRes in Bioengineering at Imperial College London. My scientific interests lie in understanding endothelial cell mechanobiology. I have previously worked on the maturation of pluripotent stem cell-derived endothelial cells into vascular subtypes under the influence of shear stress using a multiplex shear device, and also on a microfluidic system to independently apply shear stress and cyclic stretch on endothelial cells. 

My current PhD project revolves around the interaction between blood and endothelial cells (ECs) in the microvasculature. As RBCs contribute greatly to the multi-phase flow characteristics of blood that is especially apparent in microvessels, we posit that these changes in RBC behaviour inadvertently leads to modified flow within the microvessels. Specifically, the local viscosity and wall shear stress imposed on microvascular endothelial cells are altered, thus resulting in endothelial dysfunction. 

Email Adele


Anenta Ramakrishnan

I read undergraduate Medicine at Imperial College London. As part of my intercalated BSc year in Cardiovascular Sciences, I undertook a project using computational fluid dynamics and finite element analysis to model shear stress patterns in abdominal aortic aneurysms with the Department of Chemical Engineering. Following various research placements including the Academic Foundation Programme, I began my specialist training in Cardiology in the South London Deanery. I am currently embarked on a research studentship co-supervised by Professor Peter Weinberg and Professor Jamil Mayet. My aim is to understand the value of and validate the use of novel non-invasive methods of measuring arterial haemodynamics for cardiovascular risk prediction. Currently I am working with fellow team members Ethan and Ryan on the first human feasibility study of ‘Arteriowave’. This is an ultra-fast diameter-based ultrasound for deriving wave intensity analysis. We aim to be able to validate the method with ‘gold-standard’ invasive measurements, and show that it can be used to diagnose heart failure with sensitivity and specificity akin to conventional 2D trans-thoracic echocardiography.

Email Anenta


Previous Members

Members with permanent academic positions

Dr C Warboys (Postdoctoral Fellow 2015-2019)

Dr E Bailey (Postdoctoral Fellow 2011-2016)

Dr K H Fraser (Marie Cure Fellow 2011-2014)

Dr J Alastruey-Arimon (Intermed Bas Sci Fellow 2009-2011)

Dr F Palombo (Postdoctoral Fellow 2007-2009)

Dr P Vincent (PhD student 2006-2009)

Postdocs

M Ghim 2012-2019

E Bazigou 2011-2016

K Y Chooi 2016

Z Mohri 2009-2016

E Bailey 2011-2016

A P Comerford 2011-2015

L A Clarke 2009-2011

A R Bond 2008-2011

A Kazakidi 2009-2009

M Scutcher 2008-2009

L Harrington 2004-2007

B A Nier 2002-2007

S G Cremers 2002-2005

M K Shaw 2001-2002

T J Staughton 2000-2002

Q Javed 1992-1995

A Sebkhi 1992-1995

PhD students

P Alpresa Gutiérrez 2013-2017

Y Mohamied 2012-2016

K Y Chooi 2011-2015

V Peiffer 2009-2012

M Sardalou 2009-2013

C Potter 2009-2012

A A E Hunt 2006-2010

A Kazakidi 2004-2008

A R Bond 2003-2007

C Talbot 2006-2006

E Hernandez Montes 2002-2006

B A Ewins 2001-2005

T J Staughton 1996-2000

R M Talbot 1993-1997

B A Forster 1991-1995

mres students 

M Kariman 2017-2018

S Sengupta 2017-2018

K Lichtenstein 2016-2017

K Sri Ranjan 2010-2011

S Schobesberger 2010-2011

K Y Chooi 2010-2011

E Rowland 2009-2010

C Potter 2009

Research assistants 

S E Barnes 2002-2002

R M Talbot 1992-1993

technicians

P Sowinski 2011-2016

J Del Rio 2001-2004

S Mushtaq 1999-2001

C J McGillicuddy 1999-2000

M Movassagh 1998-1999

S E Barnes 1996-1999

J P Richards 1991-1998

sabbatical visitors

Vahab Delaghi (Kermanshah University) 2011-2011

Peter has also hosted several UROP students: M. Asara, B.A. Ewins, J. Majewicz, A.R. Bond, I. Orfanidis, R. van der Mijle, A. Porter, K.Shih, V. Merkt, K. Xia, and R. Bilinski.